A woman has died and two people are injured after a two-car crash on the Mitchell Highway on Wednesday afternoon. 

Emergency services were called to the Mitchell Highway, about 20km east of Orange, just before 4.30pm on, following reports a Holden Astra and a Toyota Hilux collided.

The driver of the Holden, a 20-year-old woman, died at the scene.

The driver of the Toyota, a 32-year-old man, was treated at the scene by paramedics before being taken to Orange Health Service in a serious but stable condition.

His passenger, a 63-year-old man, was airlifted to Liverpool Hospital in a serious condition.

The road was closed for several hours as police examined the scene.

Officers attached to Canobolas Local Area Command have commenced inquiries into the circumstances surrounding the crash.

Anyone with information that may assist is urged to contact Crime Stoppers.

A report will be prepared for the information of the Coroner.

WEDNESDAY, 4.45PM:

POLICE and emergency services are on the scene of a two-car accident on the Mitchell Highway between Orange and Bathurst.

The accident occurred about 20 kilometres east of Orange around 4.30pm on Wednesday.

At this stage two people have been taken to Orange Health Service but it is unknown how many people were in the two vehicles and what condition they are in.

Transport for NSW’s livetraffic.com.au website is reporting that the highway is closed in both directions and that traffic is being diverted.

Eastbound motorists are being re-directed on to Millthorpe Road to Blayney and then the Mid Western Highway to Bathurst.

Westbound motorists are being detoured via Vittoria Road and Millthorpe Road.