The NSW Police operations over the public holidays will be targeting speeding, mobile phone, seatbelt and motorcycle helmet offences.

Chifley Police District commander Superintendent Paul McDonald says his team will be out in full force over the 10 days.

"Every highway patrol officer available will be out running 24/7 on our highways and the back roads," Supt McDonald said.

Drivers are also being urged to be aware of signs of fatigue before getting behind the wheel over the public holiday. Coming into the Easter break, 2019 has seen six more fatal car accidents than this time last year.

"We need people to really observe how they're feeling before they get on the road, have a good night's sleep, don't drive tired and take sufficient rest breaks," Supt McDonald said.

Operation Tortoise runs over the long weekend from Thursday morning to midnight on Monday.

The road safety operations will also be in place on Anzac Day, which shortly follows the Easter break, a time where loved ones travel to be together.

Operation Slow Down will begin prior to the remembrance day on Wednesday morning.

"We're out there even if you can't see us, so slow down and take your time."

With the two holidays being so close together, more cars are expected to be on the road, where many drivers are unfamiliar with the region's roads.

Regional Roads Minister Paul Toole is stressing that speeding, driving under influence and fatigue are the biggest killers on NSW roads.

"If you see those kilometres creeping up, slow down. If you're feeling tired, pull over. If you're under the influence, forget about it," Mr Toole said.

The state-wide operations will see 6500 additional officers deployed and further investments into highway and back road upgrades.