Emergency crews received reports of the accident just before 5pm, with NSW Ambulance sending two crews to the scene.

Police and other emergency services also attended.

A spokesperson for NSW Ambulance said they are assessing and treating three patients at the scene, including a man in his 20s who has controlled bleeding.

With emergency crews still at the site, drivers are advised to avoid the area.

It's been a busy few days for emergency services.

In a separate incident late Thursday night, three people were transported to hospital, one in a serious condition, after a car hit a tree near Ilford.

Emergency crews were called to the scene at around 11pm following a triple-0 call saying a car had hit a tree on Ilford Hall Road, about 200 metres from the Castlereagh Highway.

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A spokesperson for NSW Ambulance said six people were in the car at the time, with three road crews and a critical care team, including a critical care paramedic and doctor, attending the scene.

One patient, a woman in her 20s, suffered multiple fractures and suspected chest injuries in the crash.

She was treated at the scene and then taken to Westmead Hospital via road ambulance in a serious but stable condition.

Two other people were transported via road ambulance to Bathurst Health Service in a stable condition.

And on Thursday morning, a man was taken to Bathurst Base Hospital with minor injuries after two cars collided on the edge of the city's CBD.

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