It comes after a Sydney newspaper last week published new information from multiple witnesses claiming they observed a foul smell, buzzing sound and swarms of insects around the time of Ms Vaughan's disappearance at a property near Bathurst.

The property was linked to one of 47 persons of interest identified in the police investigation.

The Sydney Morning Herald also uncovered a hidden cellar within metres of where the smell and insects were identified and troubling accounts of the person of interest's behaviour and attitude towards women.

Since the new information was made public, calls have been made from the community for police to thoroughly investigate the claims, including use of cadaver dogs to search the location.

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But the State Crime Command, which has carriage of the investigation, remains tight-lipped on the development (see separate story).

Ms Vaughan's sister Kylie Spelde, thanked the public for another outpouring of support since this new evidence was published.

"So far detectives have been unable to comment on the ongoing investigation but we have full confidence the police strike force is vigorously pursuing every new lead that emerges," Ms Spelde said.

"We again would like to encourage anyone with information to come forward, particularly if they witnessed any strange or suspicious occurrences around the time of Janine's disappearance."

As the 20-year anniversary of Janine's disappearance from a Bathurst street approaches, Ms Spelde said the family had never given up hope of finally finding out what had happened to their much-loved sister and daughter.

Ms Vaughan was last seen getting into a red car on Keppel Street in the early hours of December 7, 2001 after a night out with friends.

"It is our family's deepest hope that the final piece of the jigsaw will emerge so we can bring Janine home and end the unbearable pain of not knowing what happened to her," Ms Spelde said.

"We know that this new information has raised many questions for the public, particularly in regards to the persons of interest's identity and why these witnesses are speaking up now.

"Unfortunately these questions cannot be addressed for legal reasons and due to the risk of jeopardising the ongoing investigation," she said adding, "we ask people to be mindful of that in their online comments.

"We believe there is good reason for investigating this person of interest and the family believe it is of critical importance that the claims are pursued further so they can be ruled in or out of the investigation."

Ms Spelde said she appreciates the current owners of the property in question were in a difficult situation, as they did not own the property at the time of Ms Vaughan's disappearance.

"However, we believe a thorough search would be in the best interests of everybody involved."

Ms Spelde said her family also noted that three persons of interest named at an inquest into her sister's disappearance had been cleared of any involvement by Coroner Mary Jerram.

She said the family were also still hopeful that DNA evidence seized by police which is still undergoing highly specialised forensic analysis would also yield results for the family. She reminded anyone with information about her sister's disappearance that a $1 million reward still stands.

Anyone with information on Janine Vaughan's disappearance should contact Crime Stoppers in 1800 333 000.

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